Bonnyrigg Rose manager Robbie Horn says his players can cause an upset in "the game of their lives" against Hibernian.
The junior side, the lowest-ranked club left in the Scottish Cup, take on the holders at Tynecastle in a fairytale fourth-round clash.
Bonnyrigg beat Championship Dumbarton in round three and Horn feels they can pull off another shock.
"It's been a long time coming," Horn told the Midlothian Advertiser.
"The game against Dumbarton seems like an age ago now and it's been incredibly busy.
"It's been very difficult to focus on anything else because it's such a huge one-off game - the game of their lives for a lot of the players.
"But when it comes to game time we want them to go and show people what they are capable of - that's really important to me.
"If we perform like we can, Hibs have an off day, and we get a bit of luck, you just never know. We believe we can cause an upset."
Highland League club Formartine face Premiership opposition in the shape of Partick Thistle.
Manager Kris Hunter admitted the trip to Firhill is the biggest game in their history but added: "It's also a pointer towards where we want to be going.
"Partick Thistle have a great history so it's a massive tie for us."
Hunter told the Scottish Sun: "I'd say we're the smallest club in the competition because Bonnyrigg Rose are a massive club in the junior world and have a bigger fanbase than us. But we'll go to Firhill and give it our best shot."
Stranraer, bottom of League One, parted company with boss Brian Reid just two days before their trip to Aberdeen.
Stevie Farrell was named as his replacement on Friday but will miss the match at Pittodrie after it was agreed he would remain in his current role, as assistant to Stevie Aitken at Dumbarton, for the weekend.
Farrell was previously assistant boss at Stranraer from December 2012 to May 2015, and had a playing spell with the club in the mid 1990s.
Stenhousemuir manager Brown Ferguson says there will be no pressure on his side when they tackle top-flight opponents St Johnstone.
He told the Falkirk Herald: "It's going to be a very difficult challenge for us on Saturday.
"But it's a challenge that's put down in front of you and it's there to try to rise to that occasion."
Elgin boss Jim Weir admits cup fever has got to his players ahead of the visit of Inverness.
He told the Northern Scot: "I think the closer it gets, that sort of nervous adrenaline feeling starts to kick in with the players.
"One or two of them were talking about the big crowd, talking about Saturday and also about Inverness as a team.
"There should be that sort of anticipation and people looking forward to it."
Raith's former Hearts favourite Rudi Skacel will be desperate to face his old club when the teams clash on Sunday.
Rovers boss Gary Locke is a former Hearts manager and said: "I'm not there anymore. I'm here. My only concern nowadays is Raith.
"I want to try to do as well as I possibly can here."
St Mirren have signed goalkeeper Billy O'Brien on loan from Manchester City ahead of their trip to Dundee.
The Wales Under-21 international said: "It's been a crazy couple of days but I'm ready and raring to go and I can't wait for Saturday should I be involved."
Elsewhere Alloa face Dunfermline, Ayr entertain Queen's Park, East Fife travel to Livingston, Morton take on Falkirk and Clyde visit Stirling.
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