Team England announced a number of changes across a variety of sports on Tuesday, with the inclusion of 24-year-old Jess Tappin in place of Katarina Johnson-Thompson - hot favourite to win gold in Glasgow before pulling out on Monday due to a foot problem - also catching the eye.
Chambers will focus on the individual 100 metres at next month's European Championship in Zurich after pulling out of the Commonwealth 4x100m squad, with no replacement nominated by England Athletics.
Laura Wake has been drafted in for the injured Meghan Beesley in the 400m hurdles, while Chris Thompson has been withdrawn from the 10,000m having not fully recovered from a lower leg injury. Kate Avery will compete in the 10,000m in place of Jo Pavey, who will still contest the 5,000m.
In cycling, Russ Downing has been selected to replace Jon Dibben in the men's road race after Dibben withdrew due to a broken elbow. David Fletcher will no longer compete in the mountain bike event after a fall in training, with 2006 Commonwealth champion Liam Killeen stepping in.
Judoka Caroline Kinnane has withdrawn from the -78kg event with a neck injury, being replaced by Katie-Jemima Yeats-Brown.