And just as the Liverpool striker stole all the media attention four years ago, the column space and cameras have once again been solely fixed on him as Uruguay prepare for their opening tie against Costa Rica.
This time, instead of the questionable use of his hands, it is the 27-year-old's knee attracting a mixture of concern for Uruguay and relief for his Group B opponents. An operation in late May to repair meniscus damage cast major doubts over Suarez's availability for the World Cup and it is likely he will be rested today for what is widely perceived as Uruguay's easiest test in the group stages.
However, the widespread hysteria concerning the Barclays Premier League top scorer's fitness seems to undermine an extremely strong and experienced Uruguay side who can pose a threat regardless.
Their firepower without the divisive forward is hardly lacklustre with Edinson Cavani and Diego Forlan expected to form a front pairing tonight in Fortaleza.
Forlan, who now plies his trade in the Japanese A-League, scooped up the Golden Ball award for the best player at the 2010 World Cup and played a key role in Uruguay's 2011 Copa America triumph.
While the former Manchester United man is an ageing force at 35, his set piece prowess and propensity to pull out vital goals in the biggest games is undeniable.
Equally, his strike partner Edinson Cavani boasts an enviable goal scoring record, hitting the net 25 times in 43 games in his debut season for Paris Saint-Germain.
The £55m man's hold-up ability and link play is worthy of respect, even if he does not have Suarez to collect his knock-downs. Behind them, in midfield, reside the tigerish Walter Gargano, pacy Atletico Madrid winger Cristian Rodriguez and the tricky Gaston Ramirez.
The battle-hardened defensive duo of Diego Godin and captain Diego Lugano have struck up a lengthy relationship based on strong tackling and aerial domination. Atletico defender Godin will have caught many an eye with his heroic performance in the Champions League final against Real Madrid where every ball into the danger area seemed effortlessly swept clear.
On Wednesday, he seemed undeterred by the prospect of entering the world's showpiece competition without Suarez for a short period. "We have been together practically eight years, we have been through a lot," he said. "We are ready for the good and the bad."
Lugano, his partner, is transformed in light blue, strong displays in qualifying and the Confederations Cup a far cry from those during a inconsistent season with West Bromwich Albion.
He took to Twitter on Thursday to issue a rallying call as the opening match kicked off.
"It's a characteristic of Uruguayan football that we rise from the ashes," he said. "In the toughest moments, we become even more united."
While Uruguay will hope Suarez comes out on top in his battle for fitness as he resumes training, there is hope beyond the man who continues to hog the headlines.