Chelsea again have outright possession of the top spot following their 2-0 victory over Newcastle United at Stamford Bridge.
Goals either side of the interval from Oscar and Diego Costa's 15th of the season ensured the points.
Manchester City, who began the day on top, could only manage a 1-1 draw at Everton and are now two points adrift of the leaders.
Alan Pardew enjoyed a winning start to his reign as Crystal Palace boss as his side came from behind to beat Tottenham 2-1 at Selhurst Park.
Following a goalless first half, Harry Kane's 17th goal of the season four minutes after the break gave the visitors the advantage. But Palace poured forward in search of an equaliser, with Dwight Gayle making the breakthrough in the 69th minute before Jason Puncheon scored his first goal in four months to seal a memorable day for Pardew.
At the bottom, Leicester are just two points adrift of safety as they beat Aston Villa 1-0, and have now taken seven points from their last three matches.
In another relegation battle at Turf Moor, Burnley's 2-1 triumph clinched lifted them out of the bottom three and droped QPR back into the danger zone.
In his first league match in charge of West Brom, head coach Tony Pulis conjured up a 1-0 victory over Hull at The Hawthorns thanks to Saido Berahino.
West Ham had to settle for a 1-1 draw with Swansea at the Liberty Stadium.
In the early kick-off at the Stadium of Light, Lazar Markovic's early goal gave Liverpool victory over 10-man Sunderland and move them to within four points of the top four.
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