The Scotland captain has been trying to manage a career-threatening bowel condition and, after a brief Champions League appearance against Galatasaray last week, he took a major step forward at Old Trafford by leading United to a 2-1 victory over Newcastle United in the Capital One Cup.
"It is great to be back," said the midfielder. "I have had a few reserve games and a run-out in the Champions League last week but it is good to be back, especially at Old Trafford, and in a winning team, as well."
Goals from Anderson and Tom Cleverley were enough to book a last-16 meeting with Chelsea at Stamford Bridge next month.
However, Wayne Rooney revealed Cleverley faced flak for missing a golden chance when he had been set up by Javier Hernandez.
"The manager wasn't too pleased with Tom because of that miss," said Rooney. "But it was a nice goal by him and a great strike by Anderson."