THE death toll from the ''flesh-eating'' infection rose to 12
yesterday as the Government attempted to calm public anxiety.
Chief Medical Officer Dr Kenneth Calman said there was no evidence of
any increase in the normal incidence of necrotising fasciitis.
Concern increased as more cases came to light of the disease, first
reported in Gloucestershire, which is thought to occur when
streptococcal bacteria is turned into a killer after attack by a virus.
As the British toll rose, it emerged the infection had also struck in
several other countries including Germany, Switzerland, Norway, and
Iceland.
Dr Calman said everything that could be done was being done to
investigate the wave of cases.
''Regrettably, some sporadic cases occur all the time. There is no
evidence of any increase in the normal incidence of this disease, even
taking the Gloucestershire cases into account.
''Indeed, there is no firm evidence that the other cases reported in
the media are cases of necrotising fasciitis at all. I would like to
reassure the public that there is no evidence of the incidence
increasing over the whole country, or to suggest that it will
increase.''
The search for a vaccine against the infection has been taken up by
the French, the British scientist who paved the way for them said
yesterday.
Bacteriologist Dr David Seal, now living in Glasgow, demonstrated when
he was working for the Medical Research Council in the 1980s how two
common throat germs could combine to produce the deadly gangrenous
effect, necrotising fasciitis.
Before he and his colleagues could take their work further, financial
cut-backs were imposed on the MRC throwing the future of the Clinical
Research Centre in Harrow, where he worked, into doubt.
He was one of a number of consultants who left the centre. His report
was published, but the project lay on the shelf. ''Now the French are
taking it up and have been in touch with me,'' he said. ''They are
working on it in Paris so we might see a vaccine emerge from there.''
Cuts in research funding of #10m even now are threatening the Public
Health Laboratory Service, which has been gathering vital information
about the infection, a science union claimed.
Mr John Simmons, MSF regional officer, said the proposals were
targeted on the Central Public Health laboratory in Colindale, North
London, but further cuts were imminent in 53 other labs in England
Wales.
Glasgow-based regional officer Mike Fuller said the laboratories at
Glasgow's Royal and Western Infirmary Trusts were also working ''near to
the bone'' because of demands by Greater Glasgow Health Board for cuts
and income generation equivalent to 7%.
Although the Regional Reference Laboratory at Stobhill Hospital -- the
equivalent of Colindale -- is protected so far by central funding, he
described the situation at the Western and Royal as ''a disaster waiting
to happen''.
Mr Simmons said: ''At a time when the newspapers are full of stories
of new and highly dangerous diseases it seems difficult to comprehend
why this Government is prepared to put the public health at risk by
making these cuts in an attempt to redress its public spending
deficit.''
The Medical Research Council yesterday played down the role of funding
cuts in the abandonment of Dr Seal's project. A former colleague,
Professor Peter Borriello, now working in Nottingham, described his
claim as ''nonsense''. Dr Seal had left of his own accord and could have
carried on if he wished, he said.
However, he admitted: ''The Clinical Research Centre was under review
so that the money could be spread round the country. The vaccine was
listed as a future item for review. I said it was something we would
wish to pursue but it was put lower on our list of priorities than
meningitis and another bug, clostridium difficile, which frankly were
causing more deaths.''
He added there had been mounting pressure at the time, partly
political, to devote more of resources to meningitis, ironically because
of the outbreak in Stroud, Gloucestershire, where the current cluster of
necrotising fasciitis was first centred.
Dr Seal said: ''The decision to leave was mine and that of the other
consultants, but at the end of the day this was going to take 10 years
to work through, and that kind of thing has to be done from a base where
there is security of the kind you don't get when the visiting committee
has decided the MRC is to close the place.''
The two bacteria identified by Dr Seal's research are streptococcus
pyogenes, working in synergy with a form of staphyloccocus aureus.
Only the strep bacterium has been isolated in the current batch of
cases, giving rise to speculation about an unknown virus exercising some
kind of mutation over it.
Since the recent cluster of cases drew the infection to public
attention the numbers have increased daily -- and, for the most part,
retrospectively.
Only two of the 12 known victims have still to be officially confirmed
as having suffered from necrotising fasciitis.
These are Pamela Cunningham, 25, of Bathgate, West Lothian who died in
February and an elderly patient who died in Devon last month. The latest
victim, confirmed yesterday, was a 43-year-old man who died in Cardiff
Royal Infirmary on May 1.
Health officials in Glasgow said that a reported case of necrotising
fasciitis discovered in Stobhill Hospital this week during an internal
operation on a leukemia patient did not involve the infection. The
patient died from leukemia.
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