Just one Scottish MP is expected to vote in favour of starting the official two-year process to leave the European Union.
Scottish Secretary David Mundell will back legislation to trigger Article 50 of the Lisbon treaty.
But the other 58 Scottish MPs are expected to vote against.
However, with few Tory rebels expected and the the Labour leadership on board the Conservative government is expected to win the vote comfortably.
Ministers are bracing themselves for a Supreme Court ruling on Tuesday, expected to say that MPs must have a vote.
Scotland’s Brexit minister Michael Russell confirmed that, as had been widely expected, SNP MPs would vote against the triggering of Article 50.
The Liberal Democrats have said that they will not back the legislation unless the Prime Minister agrees to a second referendum on the Brexit deal.
The Herald revealed last week that Scotland’s only Labour MP Ian Murray will defy his party leader Jeremy Corbyn and vote against.
Mr Russell said that if his party's MPs voted in favour of Article 50 they would be endorsing Theresa May's "isolationist" vision of Britain.
Last week the Prime Minister set out her plans to take the UK out of the single market when it leaves the EU.
In response First Minister Nicola Sturgeon warned that the Conservative leader had "undoubtedly" made a second independence referendum more likely.
Mr Russell said: "I don't think there is any possibility of the SNP MPs supporting the Article 50 Bill".
He added: "Endorsing Article 50 is not just endorsing the vote in the United Kingdom - and of course the vote in Scotland was very different - it's actually endorsing the type of position Theresa May has taken on the type of Brexit she wants, and that's endorsing the type of country she wants.
"She wants an isolationist country, she wants a country that is inward looking and she wants a country which is rejecting the benefits of migration. That's not the country any of us want to see Scotland being and that is one of the strongest reasons for saying we reject it."
John Lamont, the Scottish Conservative chief whip, said that Mr Russell's comments " simply confirm what we have long suspected, that the SNP has no interest in working constructively with the UK Government on Brexit."
Meanwhile, Labour faced accusations that it was being "cannibalised" by Ukip and the Liberal Democrats, as Mr Corbyn again refused to say whether or not he will force his MPs to back the triggering of Article 50.
Mr Corbyn has said he would "ask" Labour MPs to vote in favour to respect the result of the EU referendum.
Shadow Brexit secretary Sir Keir Starmer said the question of whether or not Labour would try to force MPs to vote in favour, by imposing a three-line whip, had yet to be determined.
"We're talking to colleagues, we don't know the outcome of the case," he said.
"But I'm not going to pretend that this isn't difficult for the Labour Party. There are colleagues in the PLP (parliamentary Labour Party) who are very concerned, as I am, about the outcome of the referendum."
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